TY - JOUR
T1 - Hepatitis C infection and autoimmune hemolytic anemia in a patient with colon B-cell non-hodgkin lymphoma
T2 - a case report
AU - Wahono, Singgih Pudjo
AU - Puspitasari, Yessy
N1 - Publisher Copyright:
© 2023 by SPC.
PY - 2023/11
Y1 - 2023/11
N2 - Malignant lymphoma is categorized into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Lymphoma, especially NHL, can manifest outside lymph nodes, particularly in the gastrointestinal (GI) tract. Hepatitis C virus (HCV) can induce disruptions in both the liver and other organs, with NHL being the most common extrahepatic manifestation. Secondary Autoimmune Hemolytic Anemia (AIHA) can develop in patients with lymphoproliferative disorders. A 47-year-old man presented with abdominal pain, jaundice, and weight loss. His laboratory examination revealed anemia, (direct and indirect) hyperbilirubinemia, elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), and lactate dehydrogenase (LDH), reactive anti-HCV, and positive HCV RNA. Biopsy results supported a diagnosis of B-cell NHL. In addition, imaging displayed multiple intra-abdominal lymphadenopathies. The patient was diagnosed with colon B-cell NHL primarily based on clinical symptoms and biopsy results. NHL in this patient could be attributed to HCV infection. Furthermore, the AIHA experienced by these patients may result from lymphoproliferative disorders, namely NHL.
AB - Malignant lymphoma is categorized into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Lymphoma, especially NHL, can manifest outside lymph nodes, particularly in the gastrointestinal (GI) tract. Hepatitis C virus (HCV) can induce disruptions in both the liver and other organs, with NHL being the most common extrahepatic manifestation. Secondary Autoimmune Hemolytic Anemia (AIHA) can develop in patients with lymphoproliferative disorders. A 47-year-old man presented with abdominal pain, jaundice, and weight loss. His laboratory examination revealed anemia, (direct and indirect) hyperbilirubinemia, elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), and lactate dehydrogenase (LDH), reactive anti-HCV, and positive HCV RNA. Biopsy results supported a diagnosis of B-cell NHL. In addition, imaging displayed multiple intra-abdominal lymphadenopathies. The patient was diagnosed with colon B-cell NHL primarily based on clinical symptoms and biopsy results. NHL in this patient could be attributed to HCV infection. Furthermore, the AIHA experienced by these patients may result from lymphoproliferative disorders, namely NHL.
KW - AIHA
KW - B-cell NHL
KW - hepatitis C
KW - NHL
KW - primary GI lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85174625774&partnerID=8YFLogxK
U2 - 10.48309/jmpcr.2023.181199
DO - 10.48309/jmpcr.2023.181199
M3 - Article
AN - SCOPUS:85174625774
SN - 2981-0221
VL - 5
SP - 1072
EP - 1076
JO - Journal of Medicinal and Pharmaceutical Chemistry Research
JF - Journal of Medicinal and Pharmaceutical Chemistry Research
IS - 11
ER -