TY - JOUR
T1 - Hepatitis B virus infection in Indonesia 15 years after adoption of a universal infant vaccination program
T2 - Possible impacts of low birth dose coverage and a vaccine-escape mutant
AU - Purwono, Priyo Budi
AU - Juniastuti,
AU - Amin, Mochamad
AU - Bramanthi, Rendra
AU - Nursidah,
AU - Resi, Erika Maria
AU - Wahyuni, Rury Mega
AU - Yano, Yoshihiko
AU - Soetjipto,
AU - Hotta, Hak
AU - Hayashi, Yoshitake
AU - Utsumi, Takako
AU - Lusida, Maria Inge
N1 - Funding Information:
This work was supported by grants from the National Institute of Health Research and Development, Ministry of Health and Ministry of Research and Technology of the Republic Indonesia and by the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID), the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.
Publisher Copyright:
© Copyright 2016 by The American Society of Tropical Medicine and Hygiene.
PY - 2016/9
Y1 - 2016/9
N2 - A universal hepatitis B vaccination program for infants was adopted in Indonesia in 1997. Before its implementation, the prevalence of hepatitis B surface antigen (HBsAg)-positive individuals in the general population was approximately 5-10%. The study aimed to investigate the hepatitis B virus (HBV) serological status and molecular profile among children, 15 years after adoption of a universal infant vaccination program in Indonesia. According to the Local Health Office data in five areas, the percentages of children receiving three doses of hepatitis B vaccine are high (73.9-94.1%), whereas the birth dose coverage is less than 50%. Among 967 children in those areas, the seropositive rate of HBsAg in preschool- and school-aged children ranged from 2.1% to 4.2% and 0% to 5.9%, respectively. Of the 61 HBV DNA-positive samples, the predominant genotype/subtype was B/adw2. Subtype adw3 was identified in genotype C for the first time in this population. Six samples (11.5%) had an amino acid substitution within the a determinant of the S gene region, and one sample had T140I that was suggested as a vaccine-escape mutant type. The low birth dose coverage and the presence of a vaccine-escape mutant might contribute to the endemicity of HBV infection among children in Indonesia.
AB - A universal hepatitis B vaccination program for infants was adopted in Indonesia in 1997. Before its implementation, the prevalence of hepatitis B surface antigen (HBsAg)-positive individuals in the general population was approximately 5-10%. The study aimed to investigate the hepatitis B virus (HBV) serological status and molecular profile among children, 15 years after adoption of a universal infant vaccination program in Indonesia. According to the Local Health Office data in five areas, the percentages of children receiving three doses of hepatitis B vaccine are high (73.9-94.1%), whereas the birth dose coverage is less than 50%. Among 967 children in those areas, the seropositive rate of HBsAg in preschool- and school-aged children ranged from 2.1% to 4.2% and 0% to 5.9%, respectively. Of the 61 HBV DNA-positive samples, the predominant genotype/subtype was B/adw2. Subtype adw3 was identified in genotype C for the first time in this population. Six samples (11.5%) had an amino acid substitution within the a determinant of the S gene region, and one sample had T140I that was suggested as a vaccine-escape mutant type. The low birth dose coverage and the presence of a vaccine-escape mutant might contribute to the endemicity of HBV infection among children in Indonesia.
UR - http://www.scopus.com/inward/record.url?scp=84983562882&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.15-0121
DO - 10.4269/ajtmh.15-0121
M3 - Article
C2 - 27402524
AN - SCOPUS:84983562882
SN - 0002-9637
VL - 95
SP - 674
EP - 679
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 3
ER -
