TY - JOUR
T1 - Heat Shock Factor 1 Inhibition
T2 - A Novel Anti-Cancer Strategy with Promise for Precision Oncology
AU - Gumilar, Khanisyah Erza
AU - Chin, Yeh
AU - Ibrahim, Ibrahim Haruna
AU - Tjokroprawiro, Brahmana A.
AU - Yang, Jer Yen
AU - Zhou, Ming
AU - Gassman, Natalie R.
AU - Tan, Ming
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/11
Y1 - 2023/11
N2 - Heat shock factor 1 (HSF1) is a transcription factor crucial for regulating heat shock response (HSR), one of the significant cellular protective mechanisms. When cells are exposed to proteotoxic stress, HSF1 induces the expression of heat shock proteins (HSPs) to act as chaperones, correcting the protein-folding process and maintaining proteostasis. In addition to its role in HSR, HSF1 is overexpressed in multiple cancer cells, where its activation promotes malignancy and leads to poor prognosis. The mechanisms of HSF1-induced tumorigenesis are complex and involve diverse signaling pathways, dependent on cancer type. With its important roles in tumorigenesis and tumor progression, targeting HSF1 offers a novel cancer treatment strategy. In this article, we examine the basic function of HSF1 and its regulatory mechanisms, focus on the mechanisms involved in HSF1′s roles in different cancer types, and examine current HSF1 inhibitors as novel therapeutics to treat cancers.
AB - Heat shock factor 1 (HSF1) is a transcription factor crucial for regulating heat shock response (HSR), one of the significant cellular protective mechanisms. When cells are exposed to proteotoxic stress, HSF1 induces the expression of heat shock proteins (HSPs) to act as chaperones, correcting the protein-folding process and maintaining proteostasis. In addition to its role in HSR, HSF1 is overexpressed in multiple cancer cells, where its activation promotes malignancy and leads to poor prognosis. The mechanisms of HSF1-induced tumorigenesis are complex and involve diverse signaling pathways, dependent on cancer type. With its important roles in tumorigenesis and tumor progression, targeting HSF1 offers a novel cancer treatment strategy. In this article, we examine the basic function of HSF1 and its regulatory mechanisms, focus on the mechanisms involved in HSF1′s roles in different cancer types, and examine current HSF1 inhibitors as novel therapeutics to treat cancers.
KW - HSF1
KW - cancer stem cells
KW - cellular stress
KW - heat shock response
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85176570073&partnerID=8YFLogxK
U2 - 10.3390/cancers15215167
DO - 10.3390/cancers15215167
M3 - Review article
AN - SCOPUS:85176570073
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 21
M1 - 5167
ER -