TY - JOUR
T1 - Gripa porcină A(H5N1), Indonezia
AU - Nidom, Chairul A.
AU - Takano, Ryo
AU - Yamada, Shinya
AU - Sakai-Tagawa, Yuko
AU - Daulay, Syafril
AU - Aswadi, Didi
AU - Suzuki, Takashi
AU - Suzuki, Yasuo
AU - Shinya, Kyoko
AU - Iwatsuki-Horimoto, Kiyoko
AU - Muramoto, Yukiko
AU - Kawaoka, Yoshihiro
N1 - Funding Information:
This work was supported by a grant-in-aid for Specially Promoted Research, Japan; a contract research fund for the Program of Funding Research Centers for Emerging and Reemerging Infectious Diseases from the Ministries of Education, Culture, Sports, Science, and Technology, Japan; grants-in-aid of Health, Labor, and Welfare, Japan; an Exploratory Research for Advanced Technology grant from Japan Science and Technology Agency, Japan; and by National Institute of Allergy and Infectious Diseases Public Health Service research grants, USA.
Publisher Copyright:
© 2010, Amaltea Medical Publishing House. All rights reserved.
PY - 2010
Y1 - 2010
N2 - Pigs have long been considered potential intermediate hosts in which avian infl uenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005–2009. We found that 52 pigs in 4 provinces were infected during 2005–2007 but not 2008–2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had infl uenza-like symptoms, indicating that infl uenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of infl uenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.
AB - Pigs have long been considered potential intermediate hosts in which avian infl uenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005–2009. We found that 52 pigs in 4 provinces were infected during 2005–2007 but not 2008–2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had infl uenza-like symptoms, indicating that infl uenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of infl uenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.
KW - avian infl uenza viruses
KW - host
UR - http://www.scopus.com/inward/record.url?scp=85142800075&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85142800075
SN - 1454-3389
VL - 13
SP - 194
EP - 202
JO - Romanian Journal of Infectious Diseases
JF - Romanian Journal of Infectious Diseases
IS - 4
ER -
