Golden sea cucumbers (Stichopus Hermanii) as growth factors of stem cells

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15 Citations (Scopus)


Stem cells can give a new hope to accelerate wound healing process and can also be used for the treatment of various diseases, including diseases on periodontal tissues (periodontitis) since there is still not any materials known to be able to attach wobbly teeth perfectly. Adult stem cells derived from bone marrow have widely been used nowadays. However, the number of stem cells is limited, consequently, growth factors are necessary to increase the proliferation of stem cells. Unfortunately, growth factors that have been used are still expensive and difficult to obtain. Therefore, an alternative to the use of growth factors from natural materials that can potentially accelerate wound healing process is necessary to be developed. Purpose: Golden Sea Cucumbers (Stichopus hermanii) is rich in both growth factors that can repair damaged cells and protein that reaches up to 82% of all components of the golden sea cucumbers, 80% of which is collagen. Therefore, this research aims to prove how great the potential of the Golden Sea Cucumbers (Stichopus hermanii) as natural growth factors on stem cells is. Method conducted aimed to analyze proliferation ability and osteogenic differentiation in Mesenchymal Stem Cells (MSC) with the provision of the Golden Sea Cucumbers (Stichopus hermanii). Results: Based on the results of MTT assay, the provision of the Golden Sea Cucumbers (Stichopus hermanii) in cultured MSCs could enhance the proliferation of stem cells. In the provision of osteogenic induction medium, mineralization emerged in MSC culture, stained with alizarin red. The provision of the Golden Sea Cucumbers on MSC can improve the proliferation ability of MSC and can also increase the ability of MSCs to differentiate into osteoblasts.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 2016


  • Golden sea cucumbers (Stichopus hermani)
  • Growth factors
  • Mesenchymal stem cells


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