TY - JOUR
T1 - Gold Nanoparticle Synthesized from Centella asiatica
T2 - Emphasis on Optimization, Characterization, Antioxidant, Antiglycation, and Cytotoxicity Effect as an Anti-aging Cosmetic Ingredient
AU - Ruth, Feliadewi
AU - Soeratri, Widji
AU - Hariyadi, Dewi Melani
AU - Septiana, Eris
AU - Muttaqien, Sjaikhurrizal El
AU - Munfadlila, Asef Wildan
AU - Sekaringtyas, Fransiska Christydira
AU - Rosyidah, A’liyatur
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2025/3
Y1 - 2025/3
N2 - This study aimed to synthesize AuNPs utilizing Centella asiatica leaf extract as a bioreductor of Au3+ to Au0 for cosmeceutical uses. The green synthesis approach was chosen for this study due to its various advantages, including its simplicity, eco-friendliness, and low cost. In this work, multiple pHs (acid, neutral, and alkaline), temperatures (25, 37, 50, and 70 °C), and plant concentrations (2, 4, 6, 8, and 10%) were utilized to optimize the synthesis process. The results showed that the suitable conditions for synthesizing AuNPs were at 70 °C, pH 7, and 4% concentration of C. asiatica extract. The UV–Vis spectra identified an SPR with a maximum wavelength of 526 nm, indicating the SPR spectra of AuNPs. SEM, EDX, TEM, FTIR, and XRD were used to characterize the synthesized AuNPs. The chemical elements comprised 13.6% Au and had spherical, rod, triangular, and hexagonal shapes. The AuNPs form a crystallinity profile based on the Bragg reflection of gold nanocrystals. The study was extended by examining anti-aging efficiency using stability, moisture retention, glycation, antioxidant, and cytotoxicity assay. AuNPs exhibit good stability since they do not change the SPR and zeta potential value after the stability test. The percentage inhibition value of AuNPs for the glycation assay was 95.30 + 3.51%. Moreover, the AuNPs do not exhibit cytotoxic activity at various concentrations from 6.25 to 100 μg/mL in NIH-3T3 mouse fibroblast cells. These findings suggest that the AuNPs synthesized utilizing C. asiatica could be a promising candidate for cosmetic components with anti-aging properties.
AB - This study aimed to synthesize AuNPs utilizing Centella asiatica leaf extract as a bioreductor of Au3+ to Au0 for cosmeceutical uses. The green synthesis approach was chosen for this study due to its various advantages, including its simplicity, eco-friendliness, and low cost. In this work, multiple pHs (acid, neutral, and alkaline), temperatures (25, 37, 50, and 70 °C), and plant concentrations (2, 4, 6, 8, and 10%) were utilized to optimize the synthesis process. The results showed that the suitable conditions for synthesizing AuNPs were at 70 °C, pH 7, and 4% concentration of C. asiatica extract. The UV–Vis spectra identified an SPR with a maximum wavelength of 526 nm, indicating the SPR spectra of AuNPs. SEM, EDX, TEM, FTIR, and XRD were used to characterize the synthesized AuNPs. The chemical elements comprised 13.6% Au and had spherical, rod, triangular, and hexagonal shapes. The AuNPs form a crystallinity profile based on the Bragg reflection of gold nanocrystals. The study was extended by examining anti-aging efficiency using stability, moisture retention, glycation, antioxidant, and cytotoxicity assay. AuNPs exhibit good stability since they do not change the SPR and zeta potential value after the stability test. The percentage inhibition value of AuNPs for the glycation assay was 95.30 + 3.51%. Moreover, the AuNPs do not exhibit cytotoxic activity at various concentrations from 6.25 to 100 μg/mL in NIH-3T3 mouse fibroblast cells. These findings suggest that the AuNPs synthesized utilizing C. asiatica could be a promising candidate for cosmetic components with anti-aging properties.
KW - Anti-aging
KW - Antioxidant
KW - Centella asiatica
KW - Gold nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85211372629&partnerID=8YFLogxK
U2 - 10.1007/s12668-024-01713-5
DO - 10.1007/s12668-024-01713-5
M3 - Article
AN - SCOPUS:85211372629
SN - 2191-1630
VL - 15
JO - BioNanoScience
JF - BioNanoScience
IS - 1
M1 - 45
ER -