Genotypic characterization of human immunodeficiency virus type 1 derived from antiretroviral therapy-naive individuals residing in Sorong, West Papua

Adiana Mutamsari Witaningrum, Tomohiro Kotaki, Siti Qamariyah Khairunisa, M. Muhammad Qushai Yunifiar, Dwi Wahyu Indriati, Rendra Bramanthi, Nasronudin, Masanori Kameoka

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18 Citations (Scopus)

Abstract

Papua and West Papua provinces have the highest prevalence rate of human immunodeficiency virus type 1 (HIV-1) infection in Indonesia; however, data on the molecular epidemiology of HIV-1 are limited. We conducted a genotypic study on HIV-1 genes derived from antiretroviral therapy-naive individuals residing in Sorong, West Papua. HIV-1 genomic fragments were amplified from 43 peripheral blood samples, and sequencing analysis of the genes was carried out. Of the 43 samples, 41 protease (PR), 31 reverse transcriptase (RT), 26 gag, and 25 env genes were sequenced. HIV-1 subtyping revealed that CRF01-AE (48.8%, 21/43) and subtype B (41.9%, 18/43) were the major subtypes prevalent in the region, whereas other recombinant forms were also detected. Major drug resistance-associated mutations for PR inhibitors were not detected; however, mutations for the RT inhibitors, A62V and E138A, appeared in a few samples, indicating the possible emergence of transmitted HIV-1 drug resistance in Sorong, West Papua.

Original languageEnglish
Pages (from-to)812-817
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume32
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

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