TY - JOUR
T1 - Genotypic Characterization of Human Immunodeficiency Virus Type 1 Isolated from Antiretroviral Treatment-Experienced Individuals in Buleleng Regency, Bali, Indonesia
AU - Megasari, Ni Luh Ayu
AU - Oktafiani, Devi
AU - Ana, Elsa Fitri
AU - Ueda, Shuhei
AU - Kotaki, Tomohiro
AU - Nasronudin,
AU - Soetjipto,
AU - Kameoka, Masanori
N1 - Publisher Copyright:
© 2019, Mary Ann Liebert, Inc.
PY - 2019/8
Y1 - 2019/8
N2 - Bali, the first province to report a case of HIV in 1987, was placed sixth among Indonesian provinces with the highest cumulative number of HIV cases in 2017. As a popular tourist destination, the spread of genetic variants of HIV through international travel may become a cause for concern in Bali. Tourism is mostly concentrated in south Bali; thus, HIV in less popular regions in north Bali, such as Buleleng Regency, may have viral characteristics different from that in south Bali. Forty-three protease (PR), 40 reverse transcriptase (RT), 27 gag, and 23 env genes were sequenced from 48 samples derived from antiretroviral treatment-experienced individuals. Subtyping revealed CRF01-AE as the dominant circulating recombinant form of HIV-1 in north Bali. Although no major mutation was detected in PR genes, several major mutations were identified in 4 out of the 40 RT genes (10%), indicating the emergence of HIV-1 drug resistance in this region.
AB - Bali, the first province to report a case of HIV in 1987, was placed sixth among Indonesian provinces with the highest cumulative number of HIV cases in 2017. As a popular tourist destination, the spread of genetic variants of HIV through international travel may become a cause for concern in Bali. Tourism is mostly concentrated in south Bali; thus, HIV in less popular regions in north Bali, such as Buleleng Regency, may have viral characteristics different from that in south Bali. Forty-three protease (PR), 40 reverse transcriptase (RT), 27 gag, and 23 env genes were sequenced from 48 samples derived from antiretroviral treatment-experienced individuals. Subtyping revealed CRF01-AE as the dominant circulating recombinant form of HIV-1 in north Bali. Although no major mutation was detected in PR genes, several major mutations were identified in 4 out of the 40 RT genes (10%), indicating the emergence of HIV-1 drug resistance in this region.
KW - ART
KW - CRF01-AE
KW - Indonesia
KW - north Bali
UR - http://www.scopus.com/inward/record.url?scp=85070417346&partnerID=8YFLogxK
U2 - 10.1089/aid.2019.0058
DO - 10.1089/aid.2019.0058
M3 - Article
C2 - 31112033
AN - SCOPUS:85070417346
SN - 0889-2229
VL - 35
SP - 769
EP - 774
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 8
ER -
