TY - JOUR
T1 - Genotype and Subtype Analyses of Hepatitis B Virus (HBV) and Possible Co-Infection of HBV and Hepatitis C Virus (HCV) or Hepatitis D Virus (HDV) in Blood Donors, Patients with Chronic Liver Disease and Patients on Hemodialysis in Surabaya, Indonesia
AU - Lusida, Maria I.
AU - Surayah,
AU - Sakugawa, Hiroshi
AU - Nagano-Fujii, Motoko
AU - Soetjipto,
AU - Mulyanto,
AU - Handajani, Retno
AU - Boediwarsono,
AU - Setiawan, Poernomo B.
AU - Nidom, Chairul A.
AU - Ohgimoto, Shinji
AU - Hotta, Hak
PY - 2003
Y1 - 2003
N2 - Four subtypes (adw, adr, ayw, and ayr) and eight genotypes (A to H) of the hepatitis B virus (HBV) have been identified. They appear to be associated with particular geographic distribution, ethnicity, and possibly clinical outcomes. In this study, hepatitis B surface antigen (HBsAg) subtyping and HBV genotyping were carried out on sera obtained from HBsAg-positive HBV carriers, including healthy blood donors; patients with acute hepatitis, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma; and patients on hemodialysis all located in Surabaya, Indonesia. We report here that all HBV isolates tested in Surabaya belonged to genotype B, with more than 90% of them being classified into subtype adw. Our results also revealed that prevalence of hepatitis C virus (HCV) co-infection among HBV carriers in Surabaya was approximately 10% for healthy blood donors and patients with chronic liver disease, and approximately 60% for patients on maintenance hemodialysis. Interestingly, HBsAg titers were lower in HBV carriers with HCV co-infection than in those without HCV co-infection. We also found that prevalence of hepatitis D virus (HDV) co-infection was <0.5% among HBV carriers in Surabaya.
AB - Four subtypes (adw, adr, ayw, and ayr) and eight genotypes (A to H) of the hepatitis B virus (HBV) have been identified. They appear to be associated with particular geographic distribution, ethnicity, and possibly clinical outcomes. In this study, hepatitis B surface antigen (HBsAg) subtyping and HBV genotyping were carried out on sera obtained from HBsAg-positive HBV carriers, including healthy blood donors; patients with acute hepatitis, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma; and patients on hemodialysis all located in Surabaya, Indonesia. We report here that all HBV isolates tested in Surabaya belonged to genotype B, with more than 90% of them being classified into subtype adw. Our results also revealed that prevalence of hepatitis C virus (HCV) co-infection among HBV carriers in Surabaya was approximately 10% for healthy blood donors and patients with chronic liver disease, and approximately 60% for patients on maintenance hemodialysis. Interestingly, HBsAg titers were lower in HBV carriers with HCV co-infection than in those without HCV co-infection. We also found that prevalence of hepatitis D virus (HDV) co-infection was <0.5% among HBV carriers in Surabaya.
KW - Genotype
KW - Hepatitis B virus
KW - Indonesia
KW - Subtype
UR - http://www.scopus.com/inward/record.url?scp=9144222186&partnerID=8YFLogxK
U2 - 10.1111/j.1348-0421.2003.tb03457.x
DO - 10.1111/j.1348-0421.2003.tb03457.x
M3 - Article
C2 - 14695447
AN - SCOPUS:9144222186
SN - 0385-5600
VL - 47
SP - 969
EP - 975
JO - Microbiology and Immunology
JF - Microbiology and Immunology
IS - 12
ER -