Genotype and Subtype Analyses of Hepatitis B Virus (HBV) and Possible Co-Infection of HBV and Hepatitis C Virus (HCV) or Hepatitis D Virus (HDV) in Blood Donors, Patients with Chronic Liver Disease and Patients on Hemodialysis in Surabaya, Indonesia

Maria I. Lusida, Surayah, Hiroshi Sakugawa, Motoko Nagano-Fujii, Soetjipto, Mulyanto, Retno Handajani, Boediwarsono, Poernomo B. Setiawan, Chairul A. Nidom, Shinji Ohgimoto, Hak Hotta

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Four subtypes (adw, adr, ayw, and ayr) and eight genotypes (A to H) of the hepatitis B virus (HBV) have been identified. They appear to be associated with particular geographic distribution, ethnicity, and possibly clinical outcomes. In this study, hepatitis B surface antigen (HBsAg) subtyping and HBV genotyping were carried out on sera obtained from HBsAg-positive HBV carriers, including healthy blood donors; patients with acute hepatitis, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma; and patients on hemodialysis all located in Surabaya, Indonesia. We report here that all HBV isolates tested in Surabaya belonged to genotype B, with more than 90% of them being classified into subtype adw. Our results also revealed that prevalence of hepatitis C virus (HCV) co-infection among HBV carriers in Surabaya was approximately 10% for healthy blood donors and patients with chronic liver disease, and approximately 60% for patients on maintenance hemodialysis. Interestingly, HBsAg titers were lower in HBV carriers with HCV co-infection than in those without HCV co-infection. We also found that prevalence of hepatitis D virus (HDV) co-infection was <0.5% among HBV carriers in Surabaya.

Original languageEnglish
Pages (from-to)969-975
Number of pages7
JournalMicrobiology and Immunology
Volume47
Issue number12
DOIs
Publication statusPublished - 2003

Keywords

  • Genotype
  • Hepatitis B virus
  • Indonesia
  • Subtype

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