TY - JOUR
T1 - Genetic characterization of H5N1 influenza viruses isolated from chickens in Indonesia in 2010
AU - Nidom, Chairul A.
AU - Yamada, Shinya
AU - Nidom, Reviany V.
AU - Rahmawati, Kadek
AU - Alamudi, Muhamad Y.
AU - Kholik,
AU - Indrasari, Setyarina
AU - Hayati, Ratnani S.
AU - Iwatsuki Horimoto, Kiyoko
AU - Kawaoka, Yoshihiro
N1 - Funding Information:
Acknowledgments We thank Susan Watson for editing the manuscript. This study was supported by ERATO (Japan Science and Technology Agency), by a grant-in-aid for Specially Promoted Research, by the Japan Initiative for Global Research Network on Infectious Diseases from the Ministries of Education, Culture, Sports, Science, and Technology of Japan, by grants-in-aid from Health, Labor, and Welfare of Japan, by an NIAID-funded Center for Research on Influenza Pathogenesis (CRIP, HHSN266200700010C), by National Institute of Allergy and Infectious Disease Public Health Service research grants, USA, and by EU-WHO project No.SE/09/ 128014.
PY - 2012/6
Y1 - 2012/6
N2 - Since 2003, highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry in Indonesia every year, producing the highest number of human victims worldwide. However, little is known about the H5N1 influenza viruses that have been circulating there in recent years. We therefore conducted surveillance studies and isolated eight H5N1 viruses from chickens. Phylogenic analysis of their hemagglutinin and neuraminidase genes revealed that all eight viruses belonged to clade 2.1.3.However, on the basis of nucleotide differences, these viruses could be divided into two groups. Other viruses genetically closely related to these two groups of viruses were all Indonesian isolates, suggesting that these new isolates have been evolving within Indonesia. Among these viruses, two distinct viruses circulated in the Kalimantan islands during the same season in 2010. Our data reveal the continued evolution of H5N1 viruses in Indonesia.
AB - Since 2003, highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry in Indonesia every year, producing the highest number of human victims worldwide. However, little is known about the H5N1 influenza viruses that have been circulating there in recent years. We therefore conducted surveillance studies and isolated eight H5N1 viruses from chickens. Phylogenic analysis of their hemagglutinin and neuraminidase genes revealed that all eight viruses belonged to clade 2.1.3.However, on the basis of nucleotide differences, these viruses could be divided into two groups. Other viruses genetically closely related to these two groups of viruses were all Indonesian isolates, suggesting that these new isolates have been evolving within Indonesia. Among these viruses, two distinct viruses circulated in the Kalimantan islands during the same season in 2010. Our data reveal the continued evolution of H5N1 viruses in Indonesia.
KW - Genetic characterization
KW - H5N1 influenza virus
KW - Indonesia
KW - Phylogenic analysis
UR - http://www.scopus.com/inward/record.url?scp=84863719204&partnerID=8YFLogxK
U2 - 10.1007/s11262-012-0722-0
DO - 10.1007/s11262-012-0722-0
M3 - Article
C2 - 22323117
AN - SCOPUS:84863719204
SN - 0920-8569
VL - 44
SP - 459
EP - 465
JO - Virus Genes
JF - Virus Genes
IS - 3
ER -
