Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence

Muhammad Miftahussurur, Dalla Doohan, Iswan Abbas Nusi, Pangestu Adi, Yudith Annisa Ayu Rezkitha, Langgeng Agung Waskito, Kartika Afrida Fauzia, Taufan Bramantoro, Ummi Maimunah, Husin Thamrin, Safitri Indah Masithah, Sukadiono Sukadiono, Tomohisa Uchida, Maria Inge Lusida, Yoshio Yamaoka

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. We recruited 104 dyspeptic patients who underwent endoscopy in Surabaya. Patients were diagnosed with GERD based on the Los Angeles classification. We evaluated gastric biopsy specimens and measured serum pepsinogen levels. Interleukin polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Of 104 patients, 56 (53.8%) were endoscopically found to have GERD, with most categorized as grade A; 48 (46.2%) were classified as non-GERD. Higher economic status, smoking, and a history of proton-pump inhibitor use significantly increased the risk of GERD. GERD Questionnaire scores showed a positive correlation with GERD (P < 0.001). An association was found between antral atrophic gastritis and GERD (P = 0.030), and patients with GERD more frequently had severe antral atrophy than nonerosive reflux disease (P = 0.018). We found an association between pepsinogen I/II levels and GERD (P = 0.047), but with low accuracy. IL-1β -511 TT and CT were predominant among the IL-1β -511 genotypes, and IL-8-251 AT and TT were predominant among the IL-8-251 genotypes. In conclusion, we found a high prevalence of GERD in an area with low prevalence of H. pylori infection, which could be associated with acid reflux. Smoking, history of proton-pump inhibitor use, and higher economic group significantly increased the risk of GERD.

Original languageEnglish
Article numbere0205644
JournalPLoS ONE
Volume13
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

Fingerprint

Dive into the research topics of 'Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence'. Together they form a unique fingerprint.

Cite this