Gambaran Nekrosis Hepar Mencit yang Diinduksi Monosodium Glutamat dan Ekstrak Methanol Biji Kopi Robusta (Coffea Canephora)

This study aimed to analyze the effect of methanol robusta coffee bean extract (Coffea canephora) on liver histopathological description in mice induced with monosodium glutamate (MSG). This study was used 20 male mice for 5 treatment groups: K + (MSG 0.12 mg and Vitamin C 6 mg), K- (MSG 0.12 mg and CMC Na 0.1 ml), P1 (MSG 0.12 mg andRCE 0.1 mg), P2 (MSG 0.12 mg andRCE 0.2 mg), andP3 (MSG 0.12 mg andRCE 0.4 mg) per orally for 42 days. Liver histological scores were analyzed using Kruskal Wallis test. The results of Kruskal Wallis test scoredp=0,391 which indicates that the data is not significant (p>0.05). In the control and treatment groups there were no significant. In conclusion, the giving methanol robusta coffee bean extract did not show a decrease in hepatosite damage that was different from the negative control treatment group.