Fusion protein of aminoacid mutations in Newcastle disease isolated from swan goose caused resistance to infection

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Abstract

Newcastle disease virus (NDV) cloacal swab were collected from unvaccinated swan goose and isolated by inoculation in Specific Pathogen Free embryonated eggs. Haemagglutination and Haemagglutination inhibition tests were done to identify and the, samples were processed to one step Reverse Transcriptase –Polymerase Chain Reaction using primer that amplified sequences of fusion (F) gene. Deduced amino acid sequence of the cleavage site of fusion (F) protein revealed that all isolates had avirulent motifs. Amino acid mutations that occurred were analyzed to the same reference sequence. The result showed that amino acid mutations was not capable of changing the virulence of the virus.

Original languageEnglish
Pages (from-to)53-55
Number of pages3
JournalIndian Veterinary Journal
Volume96
Issue number10
Publication statusPublished - 2019

Keywords

  • : Newcastle disease virus (NDV)
  • Amino acid
  • Mutations
  • Virulence

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