Abstract

The prevalence of gingivitis and periodontitis in Indonesia is still high at 74% and 74.1%, respectively. The inflammatory process cause pain that affect the children's quality of life. Ibuprofen often used has side effects on kidney function, blood pressure, and gastrointestinal. The in silico study is an experiment using a computational method to determine the potential and mechanism of fractionated ethanol extract of red ginger (Zingiber officinale var. rubrum) as an anti-inflammatory drug candidate. PASS Online to analyze the anti-inflammatory, PyRx 0.8 to run and analyze molecular docking, STRING to analyze pathway mechanisms involved in the anti-inflammatory process. There were 3 compounds having a Pa value more than 0.7, i.e. bisabolene, curcumene, and shogaol. Red ginger compounds having more negative binding affinity score than ibuprofen were gamma-bisabolene, phenetanamine, curcumene, sesquiphellandrene, zingiberene, shogaol, and 6-gingerol. Fractionated ethanol extract of red ginger is predicted to have potential as an anti-inflammatory drug.

Original languageEnglish
Pages (from-to)600-605
Number of pages6
JournalJournal of International Dental and Medical Research
Volume15
Issue number2
Publication statusPublished - 2022

Keywords

  • Anti-inflammatory
  • Good health and well-being
  • Ibuprofen
  • In silico
  • Red ginger

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