Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Wiwin Is Effendi, Tatsuya Nagano, Kazuyuki Kobayashi, Yoshihiro Nishimura

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)


Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as A1AR, A2AAR, A2BAR, and A3AR, which are the center of cAMP signal pathway-based drug development. Several types of agonists, partial agonists or antagonists, and allosteric substances have been synthesized from these receptors as new therapeutic drug candidates. Research efforts surrounding A1AR and A2AAR are perhaps the most enticing because of their concentration and affinity; however, as a consequence of distressing conditions, both A2BAR and A3AR levels might accumulate. This review focuses on the biological features of each adenosine receptor as the basis of ligand production and describes clinical studies of adenosine receptor-associated pharmaceuticals in human diseases.

Original languageEnglish
Article number761
Issue number3
Publication statusPublished - 24 Mar 2020


  • G protein-coupled receptors
  • adenosine
  • adenosine receptors
  • agonists
  • allosteric molecules
  • antagonists


Dive into the research topics of 'Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases'. Together they form a unique fingerprint.

Cite this