Abstract
Background: To investigate the effect of flavonoids extract from Galing plants (Cayratia trifolia Linn) in animal model of breast cancer through changes in the expression of COX-2, cyclin D1 and wild type p53. Methods: 24 adult female Wistar strain white rats (Rattus norvegicus). Rats were divided into three groups, normal rats-non flavonoids from Galing plants extract as the normal group (G1), breast cancer rats-non flavonoids from Galing plants extractas the control group (G2) and breast cancer rats-flavonoids from Galing plants extractas the treatment group (G3). Histological examination of rat breast tissue was assessed by expression of COX-2, cyclin D1 and wild type p53 were measured by immuno-histochemistry technique. The volume of breast cancer was measured by a measuring cup. Results: There were significant decrease (p < 0.05) in the expression of the COX-2, cyclin D1 and volume of breast cancer in the G3 group compared to G2 group. The expression of wild type p53 increased significantly (p < 0.05) in the G3 group compared to G2 group . Conclusion: Flavonoids from Galing plants (Cayratia trifolia Linn) extract can be recommended to support therapy for breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 459-463 |
| Number of pages | 5 |
| Journal | International Medical Journal |
| Volume | 27 |
| Issue number | 4 |
| Publication status | Published - Aug 2020 |
Keywords
- Breast cancer
- COX-2
- Cyclin D1
- Flavonoid of galing extract
- P53 (wild type)
