Flavonoid and stilbene derivatives from Macaranga trichocarpa

Mulyadi Tanjung; Lia D. Juliawaty; Euis H. Hakim; Yana M. Syah

doi:10.1016/j.fitote.2017.10.001

Flavonoid and stilbene derivatives from Macaranga trichocarpa

Mulyadi Tanjung, Lia D. Juliawaty, Euis H. Hakim, Yana M. Syah

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A new farnesylated flavonol (4′-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC₅₀ was 3.5 μM.

Original language	English
Pages (from-to)	74-77
Number of pages	4
Journal	Fitoterapia
Volume	126
DOIs	https://doi.org/10.1016/j.fitote.2017.10.001
Publication status	Published - Apr 2018

Keywords

4′-O-Methylmacagigantin
Cytotoxicity
Euphorbiaceae
Flavonoid
Macaranga trichocarpa
Macatrichocarpin E-H
Stilbene

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title = "Flavonoid and stilbene derivatives from Macaranga trichocarpa",

abstract = "A new farnesylated flavonol (4′-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC50 was 3.5 μM.",

keywords = "4′-O-Methylmacagigantin, Cytotoxicity, Euphorbiaceae, Flavonoid, Macaranga trichocarpa, Macatrichocarpin E-H, Stilbene",

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note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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doi = "10.1016/j.fitote.2017.10.001",

language = "English",

volume = "126",

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T1 - Flavonoid and stilbene derivatives from Macaranga trichocarpa

AU - Tanjung, Mulyadi

AU - Juliawaty, Lia D.

AU - Hakim, Euis H.

AU - Syah, Yana M.

PY - 2018/4

Y1 - 2018/4

N2 - A new farnesylated flavonol (4′-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC50 was 3.5 μM.

AB - A new farnesylated flavonol (4′-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC50 was 3.5 μM.

KW - 4′-O-Methylmacagigantin

KW - Cytotoxicity

KW - Euphorbiaceae

KW - Flavonoid

KW - Macaranga trichocarpa

KW - Macatrichocarpin E-H

KW - Stilbene

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DO - 10.1016/j.fitote.2017.10.001

M3 - Article

C2 - 28986263

AN - SCOPUS:85030764594

SN - 0367-326X

VL - 126

SP - 74

EP - 77

JO - Fitoterapia

JF - Fitoterapia

ER -

Flavonoid and stilbene derivatives from Macaranga trichocarpa

Abstract

Keywords

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