TY - JOUR
T1 - Five different glucose-6-phophate dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia
AU - Matsuoka, Hiroyuki
AU - Arai, Meiji
AU - Yoshida, Shigeto
AU - Tantular, Indah Setyawati
AU - Pusarawati, Suhintam
AU - Kerong, Henyo
AU - Kawamoto, Fumihiko
PY - 2003
Y1 - 2003
N2 - We conducted a survey for malaria diagnosis and treatment in four primary schools in Flores Island, one of the Indonesian Islands with an area of 17,000 km2 and a population of 1.8 million. Of those examined, 24.4% were diagnosed as having malaria (90/363) and administered medicine immediately. A glucose-6-phophate dehydrogenase (G6PD) test was performed at the same time, and 16 persons (4.4%) were diagnosed as G6PD deficient. Eleven persons consented to analysis of the G6PD genome. We analyzed these subjects and found one case of G6PD Vanua Lava (383T > C), five cases of G6PD Coimbra (592C > T), one case of G6PD Viangchan (871G > A), one case of G6PD Chatham (1003G > A), and three cases of G6PD Kaiping (1388G > A). These were unexpected findings because five different G6PD variants were found in such a small population. This suggests that people of Flores Island are derived from various ancestries.
AB - We conducted a survey for malaria diagnosis and treatment in four primary schools in Flores Island, one of the Indonesian Islands with an area of 17,000 km2 and a population of 1.8 million. Of those examined, 24.4% were diagnosed as having malaria (90/363) and administered medicine immediately. A glucose-6-phophate dehydrogenase (G6PD) test was performed at the same time, and 16 persons (4.4%) were diagnosed as G6PD deficient. Eleven persons consented to analysis of the G6PD genome. We analyzed these subjects and found one case of G6PD Vanua Lava (383T > C), five cases of G6PD Coimbra (592C > T), one case of G6PD Viangchan (871G > A), one case of G6PD Chatham (1003G > A), and three cases of G6PD Kaiping (1388G > A). These were unexpected findings because five different G6PD variants were found in such a small population. This suggests that people of Flores Island are derived from various ancestries.
KW - Flores
KW - Glucose-6-phophate dehydrogenase deficiency
KW - Indonesia
KW - Malaria
KW - Primaquine
UR - http://www.scopus.com/inward/record.url?scp=0344441436&partnerID=8YFLogxK
U2 - 10.1007/s10038-003-0073-8
DO - 10.1007/s10038-003-0073-8
M3 - Article
C2 - 14505231
AN - SCOPUS:0344441436
SN - 1434-5161
VL - 48
SP - 541
EP - 544
JO - Journal of Human Genetics
JF - Journal of Human Genetics
IS - 10
ER -