First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid

Marcellino Rudyanto; Yuichiro Tomizawa; Hiroshi Morita; Toshio Honda

doi:10.1021/ol8004112

First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid

Marcellino Rudyanto, Yuichiro Tomizawa, Hiroshi Morita, Toshio Honda

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6-endo-dig-cyclization of phenolic oxygens to the resulting alkynes.

Original language	English
Pages (from-to)	1921-1922
Number of pages	2
Journal	Organic Letters
Volume	10
Issue number	10
DOIs	https://doi.org/10.1021/ol8004112
Publication status	Published - 15 May 2008

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title = "First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid",

abstract = "The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6-endo-dig-cyclization of phenolic oxygens to the resulting alkynes.",

author = "Marcellino Rudyanto and Yuichiro Tomizawa and Hiroshi Morita and Toshio Honda",

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T1 - First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid

AU - Rudyanto, Marcellino

AU - Tomizawa, Yuichiro

AU - Morita, Hiroshi

AU - Honda, Toshio

PY - 2008/5/15

Y1 - 2008/5/15

N2 - The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6-endo-dig-cyclization of phenolic oxygens to the resulting alkynes.

AB - The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6-endo-dig-cyclization of phenolic oxygens to the resulting alkynes.

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U2 - 10.1021/ol8004112

DO - 10.1021/ol8004112

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SP - 1921

EP - 1922

JO - Organic Letters

JF - Organic Letters

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First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid

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