Fibrinogen and Low-Density Lipoprotein (LDL) Cholesterol Levels with the Occurrence of Acute Myocardial Infarction: Is it Correlated?

Fibrinogen is considered as a risk factor associated with cardiovascular disease, especially acute myocardial infarction (AMI). The role of increasing levels of fibrinogen in the thrombosis shows that there is an effect that causes the pathway to form a thrombosis. Increased plasma high-density lipoprotein (LDL) cholesterol can also induce the development of atherosclerosis and is associated with AMI events. This study was an observational analytic study using a cross-sectional approach, carried out from August-November 2015 in Dr. Soetomo Hospital Surabaya. Samples were 67 subjects who fulfilled inclusion and exclusion criteria. A total of 67 subjects were assessed, 47 (70.15%) were males, and 20 (29.85%) were females. The mean age was 5.07 ± 11.02 years old, ranging from 30 to 85 years. AMI was diagnosed in 49 patients (26.87%). Management of AMI patients consisted of conservative medical therapy (42.86%), thrombolytic therapy (18.37%) and PPCI (38.77%). The statistical analysis revealed significant differences in plasma fibrinogen and LDL cholesterol levels between the AMI patient group and the control group. There was a significant correlation between fibrinogen levels and LDL cholesterol levels. Fibrinogen and LDL cholesterol levels are correlated with AMI risk factors. In subjects with AMI, there were higher fibrinogen and LDL cholesterol levels compared to non-AMI subjects.