Extracellular vesicles: A promising cell-free therapy for cartilage repair

Rizka Musdalifah Amsar; Christofora Hanny Wijaya; Ika Dewi Ana; Atik Choirul Hidajah; Hari Basuki Notobroto; Triati Dewi Kencana Wungu; Anggraini Barlian

doi:10.2144/fsoa-2021-0096

Extracellular vesicles: A promising cell-free therapy for cartilage repair

Rizka Musdalifah Amsar
, Christofora Hanny Wijaya
, Ika Dewi Ana
, Atik Choirul Hidajah
, Hari Basuki Notobroto
, Triati Dewi Kencana Wungu
, Anggraini Barlian

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.

Original language	English
Article number	FSO774
Journal	Future Science OA
Volume	8
Issue number	2
DOIs	https://doi.org/10.2144/fsoa-2021-0096
Publication status	Published - Feb 2022

Keywords

cartilage repair
chondrocyte
exosomes
extracellular vesicles
stem cell
therapeutic strategies

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10.2144/fsoa-2021-0096

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title = "Extracellular vesicles: A promising cell-free therapy for cartilage repair",

abstract = "Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.",

keywords = "cartilage repair, chondrocyte, exosomes, extracellular vesicles, stem cell, therapeutic strategies",

author = "Amsar, \{Rizka Musdalifah\} and Wijaya, \{Christofora Hanny\} and Ana, \{Ika Dewi\} and Hidajah, \{Atik Choirul\} and Notobroto, \{Hari Basuki\} and \{Kencana Wungu\}, \{Triati Dewi\} and Anggraini Barlian",

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doi = "10.2144/fsoa-2021-0096",

language = "English",

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T2 - A promising cell-free therapy for cartilage repair

AU - Amsar, Rizka Musdalifah

AU - Wijaya, Christofora Hanny

AU - Ana, Ika Dewi

AU - Hidajah, Atik Choirul

AU - Notobroto, Hari Basuki

AU - Kencana Wungu, Triati Dewi

AU - Barlian, Anggraini

PY - 2022/2

Y1 - 2022/2

N2 - Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.

AB - Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.

KW - cartilage repair

KW - chondrocyte

KW - exosomes

KW - extracellular vesicles

KW - stem cell

KW - therapeutic strategies

UR - https://www.scopus.com/pages/publications/85123406895

U2 - 10.2144/fsoa-2021-0096

DO - 10.2144/fsoa-2021-0096

M3 - Review article

AN - SCOPUS:85123406895

SN - 2056-5623

VL - 8

JO - Future Science OA

JF - Future Science OA

IS - 2

M1 - FSO774

ER -

Extracellular vesicles: A promising cell-free therapy for cartilage repair

Abstract

Keywords

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