TY - JOUR
T1 - Extracellular vesicles
T2 - A promising cell-free therapy for cartilage repair
AU - Amsar, Rizka Musdalifah
AU - Wijaya, Christofora Hanny
AU - Ana, Ika Dewi
AU - Hidajah, Atik Choirul
AU - Notobroto, Hari Basuki
AU - Kencana Wungu, Triati Dewi
AU - Barlian, Anggraini
N1 - Publisher Copyright:
© 2021 Anggraini Barlian.
PY - 2022/2
Y1 - 2022/2
N2 - Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.
AB - Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.
KW - cartilage repair
KW - chondrocyte
KW - exosomes
KW - extracellular vesicles
KW - stem cell
KW - therapeutic strategies
UR - http://www.scopus.com/inward/record.url?scp=85123406895&partnerID=8YFLogxK
U2 - 10.2144/fsoa-2021-0096
DO - 10.2144/fsoa-2021-0096
M3 - Review article
AN - SCOPUS:85123406895
SN - 2056-5623
VL - 8
JO - Future Science OA
JF - Future Science OA
IS - 2
M1 - FSO774
ER -