Expression of mapk and nav-1.8 in nerve cells in normal and inflamed pulp after dental pulp tissue extirpation

Galih Sampoerno, Agustina Restu Nurkhotimah, Arvia Diva Firstiana, Naufal Hafidz Adipradana, Adipradana Adipradana

Research output: Contribution to journalArticlepeer-review


The identification of dental pulp tissue may impact the risk of post-endodontic discomfort, including flare-ups. The amount of pulp tissue in teeth may influence the diagnosis of such tissue. Live pulp tissue reacts to pain more strongly than inflamed pulp. Three groups of 27 Sprague Dawley rats were used in the experimental study: a control group, a group that removed normal pulp tissue, and a group that removed inflammatory pulp tissue. Samples were taken from the mandibular incisor's apical field after the pulp tissue was extracted. Immunohistochemical techniques were employed for the examination. Before pulp tissue is extracted, LPS is administered, which causes the pulp tissue to become inflamed and results in a rise in Heat Shock Protein 70-expressing cells. Because of its overexpression, (Heat Shock Protein 70 (HSP-70( inhibits TRAF-6. Through the MAPK pathway, the drop in TRAF-6 led to a decrease in Nav1.8. When inflammatory pulp tissue is extracted, there is an overexpression of HSP70, leading to the inhibition of TRAF6. Consequently, this inhibition results in a decrease in MAPK, which subsequently lowers Nav1.8.

Original languageEnglish
Pages (from-to)245-254
Number of pages10
JournalJournal of Medicinal and Pharmaceutical Chemistry Research
Issue number3
Publication statusPublished - Mar 2024


  • MAPK
  • Nav1.8
  • Pain
  • immunology
  • pulp nerve cells


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