Expression of IL-1β in periodontitis post oral administration of papaya seed extract

Ratih Pusporini, Ahmad Basori, Agung Krismariono

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Periodontitis is a chronic inflammation induced by bacteria that can increase the expression and secretion of IL-1β. Papaya (Carica papaya linn) seed extract is rich in alkaloids, flavonoids, and phenolic acids that act as antiinflammatory. The aim of this study is to evaluate the role of papaya seed ethanol extract in periodontitis trough the expression of IL-1β. Rattus novergicus were randomly divided into five group and subject to induced LPS of P.gingivalis + ligatures on the mandibular incisive region except group C as the control group. The first group of Periodontitis (P1) was given standard diet. Meanwhile P2, P3, P4 were given extract of papaya seeds respectively 200 mg/kgBW, 300 mg/kgBW, and 400 mg/kgBW. Papaya seed extract was administered orally for 15 days. On day 16th, the rats were sacrificed and prepared for immunohistochemical evaluation with the data being analyzed using One Way ANOVA. There was a significant difference in IL-1β expression between P2,P3, P4 and the control group. Papaya (Carica papaya linn) seed extract can decrease IL-1β expression in periodontitis.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 2020


  • IL-1β
  • Inflammation
  • Papaya seed extract
  • Periodontitis


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