Expression of HSP-70 in oral chronic inflammation post-catfish (Clarias batrachus) oil application

Chronic inflammation endures for a long time and may cause oxidative stress which can increase Heat Shock Factor (HSF) and Heat Shock Protein (HSP) 70 expression. Cat fish (Clarias batrachus) oil contains Polyunsaturated Fatty Acids (PUFA) that act as antioxidants. Aim and The aim of this study is to evaluate the antioxidant effect of cat fish oil on oral mucosa chronic inflammation through the expression of HSP70. Rattus novergicus were subject to incision on the buccal mucosa and randomly divided into three groups, Group 1 as the control group, Group 2 (KP1) administered 5% cat fish oil, and Group 3 (KP2) administered 10% cat fish oil. After 3 days, cat oil was applied topically. On day 4, the rats were sacrificed and prepared for immunohistochemical evaluation with the data being analyzed using One Way ANOVA. There was a significant difference in HSP70 expression between KP2 and the control group. 10% cat fish (Clarias batrachus) oil can downgrade HSP70 expression in chronic inflammation of the oral mucosa.