In the case of surgery, it is necessary to apply a membrane barrier to provide an opportunity for the healing process for bone defects, it is because soft tissue cells migrate and develop faster than hard tissue cells. These conditions affect in the healing process of bone defects being disrupted because soft tissue that proliferates more quickly can fill the cavity of the bone defect. The membrane to be used must be biocompatible, able to regenerate bone, easy clinical application and should integrate with surrounding tissues. Thus, chitosan Is preferred as an alternative candidate for membrane barrier. Objectives to examine the expression of fibroblasts growth factor-2 (FGF2) and fibroblasts growth factor-2 receptor (FGF2R) to determine the proliferation of fibroblasts after the installation of the chitosan barrier membrane. Wistar rats were randomly into Six groups: the control group was sub into 3 smaller group based on days which is 7, 14 and 28 days same as test group; Wound was created on both side on soft tissue and hard tissue and Membrane was placed at the wound as GTR. The wistar rats were taken down on day 7, 14 and 28 days. The number of fibroblasts based on FGF2 and FGF2R expression were examined. Data was analysed using independent sample t-test (p<0.05). The expression of FGF2 and FGF2R in the application of chitosan membrane application was greater than pericardium membrane on days 7, 14 and 28 days. Chitosan membrane showed greater proliferation of fibroblasts in comparison to pericardium membrane.

Original languageEnglish
Pages (from-to)535-541
Number of pages7
JournalJournal of International Dental and Medical Research
Issue number2
Publication statusPublished - 2023


  • Chitosan
  • FGF2
  • FGF2r
  • Fibroblast
  • Immunology
  • Membrane
  • Wound healing


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