Expresión de vimentina y proteína GFAP de la corteza cerebral y su impacto en el trastorno de corticogenesis como producto del 2-metoxietanol

Translated title of the contribution: Expression of Vimentin and GFAP protein of cerebral cortex and its impact on corticogenesis disorder as a result of 2-methoxyethanol

Yulia Irnidayanti, Win Darmanto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

One of the plastic base material, widely used in the plastics industry in various countries, is a ester phthalate. These compounds will be oxidized in the body to 2-methoxyethanol (2-ME). Effect of 2-ME on human health and the environment depends on the number, duration and frequency of exposure. 2-ME and its metabolites in the body can damage cells and tissues. The body can be exposed by 2-ME through the air, water and soil. Western blot results showed that the protein Vimentin was detectable in the control group at GD-11 to 17, meanwhile GFAP protein was detachable in the control group at GD- 12 to GD-18. After administration 2-ME, the expression of Vimentin protein were changed, and started at GD- 12 up to GD-18. whereas the expression of GFAP protein began at GD- 11 up to GD-17. The Changes on timetable protein expression of Vimentin and GFAP affect corticogenesis disorder. The disorder caused by the existence of these proteins as a result of 2-Methoxyethanol. Disorder of corticogenesis process were sub-plate and cortical plate of the cerebral cortex of fetus brains of mice at GD-18. Generally, it can be concluded that changes in protein expression of Vimentin and GFAP caused by 2-ME. The Vimentin more important during the period of fetal brain development. GFAP and Vimentin is a protein involved in response to damage caused by a teratogenic agent, so that cells in the cerebral cortex, has dedifferentiation.

Translated title of the contributionExpression of Vimentin and GFAP protein of cerebral cortex and its impact on corticogenesis disorder as a result of 2-methoxyethanol
Original languageSpanish
Pages (from-to)802-808
Number of pages7
JournalInternational Journal of Morphology
Volume31
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • 2-methoxyethanol
  • Brain
  • Cerebral cortex
  • GFAP
  • Vimentin

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