Expert Opinion on Diabetes Management Challenges and Role of Basal Insulin/GLP-1 RA Fixed-Ratio Combination in People with Type 2 Diabetes from Indonesia

Ketut Suastika, Fatimah Eliana, Ida Ayu Made Kshanti, Mardianto Mardianto, Sony Wibisono Mudjarnako, Nanny Natalia, H. S. Heri Nugrohom, Roy Panusunan Sibarani, Pradana Soewondo, Soebagijo Adi Soelistijo, Tri Juli Edi Tarigan, Hendra Zufry

Research output: Contribution to journalArticlepeer-review

Abstract

Indonesia is struggling with a rapidly growing burden of diabetes due to rapid socioeconomic transition. People with type 2 diabetes mellitus (T2DM) need appropriate treatment strategies to maintain glycemic control. New modalities with simplicity, such as fixed-ratio combination of basal insulin and glucagon-like peptide-1 receptor agonist (GLP-1 RA), further referred to as FRC, have proven to be an effective and practical therapeutic approach that may address this issue. In January 2021, a scientific expert meeting was held with the participation of endocrinologists from Indonesia to provide expert opinions regarding the optimal practical use of the FRC basal insulin/GLP1-RA. Topics discussed in the meeting included the challenges in diabetes management, clinical inertia with insulin therapy, local and international guideline positioning, initiation, titration, and switching of basal insulin and GLP-1 RA, including FRC, and the management of T2DM.

Original languageEnglish
Pages (from-to)2977-2990
Number of pages14
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume15
DOIs
Publication statusPublished - 2022

Keywords

  • GLP1 RA
  • basal insulin
  • fixed-ratio combination
  • type 2 diabetes mellitus

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