Experimental and natural infections of severe acute respiratory syndrome-related coronavirus 2 in pets and wild and farm animals

Gondo Mastutik, Ali Rohman, Reny I’tishom, Ignacio Ruiz-Arrondo, Ignacio de Blas

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has spread globally and has led to extremely high mortality rates. In addition to infecting humans, this virus also has infected animals. Experimental studies and natural infections showed that dogs have a low susceptibility to SARS-CoV-2 infection, whereas domesticated cats and other animals in the family Felidae, such as lions, tigers, snow leopards, and cougars, have a high susceptibility to viral infections. In addition, wild white-tailed deer, gorillas, and otters have been found to be infected by SARS-CoV-2. Furry farm animals, such as minks, have a high susceptibility to SARS-CoV-2 infection. The virus appears to spread among minks and generate several new mutations, resulting in increased viral virulence. Furthermore, livestock animals, such as cattle, sheep, and pigs, were found to have low susceptibility to the virus, whereas chicken, ducks, turkeys, quail, and geese did not show susceptibility to SARS-CoV-2 infection. This knowledge can provide insights for the development of SARSCoV-2 mitigation strategies in animals and humans. Therefore, this review focuses on experimental (both replication and transmission) in vitro, ex vivo, and in vivo studies of SARS-CoV-2 infections in pets and in wild and farm animals, and to provide details on the mechanism associated with natural infection.

Original languageEnglish
Pages (from-to)565-589
Number of pages25
JournalVeterinary World
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 2022

Keywords

  • animal disease
  • coronavirus disease 2019
  • infectious disease
  • pandemic
  • severe acute respiratory syndrome-related coronavirus 2

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