Background: Leprosy is a tropical disease caused by Mycobacterium leprae and is characterized by damage to the skin and peripheral nerves due to direct contact with leprosy patients. Leprosy is one of the oldest diseases known to humanity, but significant gaps remain in the knowledge about this disease. Methods: This research was designed with a qualitative approach using phenomenology study. The total number of participants was 16 participants. Data were collected using in-depth interview, and NVivo 10 was used to identify themes and patterns in further data. Results: This research was conducted to explore the experience of persons affected by leprosy in facing psychosocial problems. The results of this study found three themes: Anxiety, Pulling away, Impaired self-concept Conclusion: This study has provided a prevalence rate for psychosocial problems in this group of patients. Social stigma has an essential role in persuading psychological disorders in patients with Hansen's disease. For further researchers, the early detection and treatment of psychosocial disorders among these patients was powerful.