TY - JOUR
T1 - Ex Vivo-Generated Tolerogenic Dendritic Cells
T2 - Hope for a Definitive Therapy of Autoimmune Diseases
AU - Jonny,
AU - Sitepu, Enda Cindylosa
AU - Nidom, Chairul A.
AU - Wirjopranoto, Soetojo
AU - Sudiana, I. Ketut
AU - Ansori, Arif N.M.
AU - Putranto, Terawan Agus
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/5
Y1 - 2024/5
N2 - Current therapies for autoimmune diseases are immunosuppressant agents, which have many debilitating side effects. However, dendritic cells (DCs) can induce antigen-specific tolerance. Tolerance restoration mediated by ex vivo-generated DCs can be a therapeutic approach. Therefore, in this review, we summarize the conceptual framework for developing ex vivo-generated DC strategies for autoimmune diseases. First, we will discuss the role of DCs in developing immune tolerance as a foundation for developing dendritic cell-based immunotherapy for autoimmune diseases. Then, we also discuss relevant findings from pre-clinical and clinical studies of ex vivo-generated DCs for therapy of autoimmune diseases. Finally, we discuss problems and challenges in dendritic cell therapy in autoimmune diseases. Throughout the article, we discuss autoimmune diseases, emphasizing SLE.
AB - Current therapies for autoimmune diseases are immunosuppressant agents, which have many debilitating side effects. However, dendritic cells (DCs) can induce antigen-specific tolerance. Tolerance restoration mediated by ex vivo-generated DCs can be a therapeutic approach. Therefore, in this review, we summarize the conceptual framework for developing ex vivo-generated DC strategies for autoimmune diseases. First, we will discuss the role of DCs in developing immune tolerance as a foundation for developing dendritic cell-based immunotherapy for autoimmune diseases. Then, we also discuss relevant findings from pre-clinical and clinical studies of ex vivo-generated DCs for therapy of autoimmune diseases. Finally, we discuss problems and challenges in dendritic cell therapy in autoimmune diseases. Throughout the article, we discuss autoimmune diseases, emphasizing SLE.
KW - autoimmune disease
KW - cellular immunotherapy
KW - dendritic cells
KW - immune tolerance
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85194224322&partnerID=8YFLogxK
U2 - 10.3390/cimb46050249
DO - 10.3390/cimb46050249
M3 - Review article
AN - SCOPUS:85194224322
SN - 1467-3037
VL - 46
SP - 4035
EP - 4048
JO - Current Issues in Molecular Biology
JF - Current Issues in Molecular Biology
IS - 5
ER -