TY - JOUR
T1 - Evaluation of the Impact of Sodium Fluoride on Amelogenesis in Rattus Novergicus
AU - Wahluyo, Soegeng
AU - Ismiyatin, Kun
AU - Nuraini, Prawati
AU - Wahjuningrum, Dian Agustin
AU - Hariadi, Rhena Reifa
AU - Dewi, Ardianti Maartina
AU - Thakur, Bhagyashree
AU - Vinay, Vineet
AU - Anindya, Cinitra
N1 - Funding Information:
The authors are grateful to the Ministry of Research, Technology and Higher Education, Indonesia, for the funding support thus this research oculd ebconducted.
Publisher Copyright:
© (2023), (University of Dicle). All Rights Reserved.
PY - 2023
Y1 - 2023
N2 - Amelogenesis is driven by a number of exceedingly complicated elements, components, and processes. Each component, such as the Amelogenin protein and the proteinase MMP-20, performs critical and strategic functions. Fluoride exposure at particular doses and durations changes the amount of ameloblast cells necessary for the process of amelogenesis. The results of this study showed that sodium fluoride induction accelerated the breakdown of fragments into smaller Amelogenin proteins, decreased the function of caspase-3 in the drawn-out process of apoptosis, and increased the involvement of MMP-20 and Calmodulin-28kDa in the process of protein degradation. The spacing between ameloblast cells and their density would stay the same because there was no substantial cell dying mechanism. However, the matrix of the tooth enamel exposed to fluoride would become denser. The scientists found that causing sodium fluoride in fluoride-exposed teeth could maintain ameloblast cell viability and enhance dental amelogenesis.
AB - Amelogenesis is driven by a number of exceedingly complicated elements, components, and processes. Each component, such as the Amelogenin protein and the proteinase MMP-20, performs critical and strategic functions. Fluoride exposure at particular doses and durations changes the amount of ameloblast cells necessary for the process of amelogenesis. The results of this study showed that sodium fluoride induction accelerated the breakdown of fragments into smaller Amelogenin proteins, decreased the function of caspase-3 in the drawn-out process of apoptosis, and increased the involvement of MMP-20 and Calmodulin-28kDa in the process of protein degradation. The spacing between ameloblast cells and their density would stay the same because there was no substantial cell dying mechanism. However, the matrix of the tooth enamel exposed to fluoride would become denser. The scientists found that causing sodium fluoride in fluoride-exposed teeth could maintain ameloblast cell viability and enhance dental amelogenesis.
KW - Amelogenesis/Sodium Fluoride
KW - Amelogenin
KW - Caspase-3
KW - MMP-20
KW - calmodulin-28kDa
UR - http://www.scopus.com/inward/record.url?scp=85173514002&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85173514002
SN - 1309-100X
VL - 16
SP - 1098
EP - 1103
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 3
ER -