TY - GEN
T1 - Evaluation of the Antimicrobial Activity of Curcuma mangga Nanoparticles In Vitro
AU - Muchtaromah, Bayyinatul
AU - Fitriasari, Prilya Dewi
AU - Azizah, Malikah
AU - Ahmad, Mujahidin
AU - Hayati, Alfiah
AU - Fajriyah, Ely Nuril
N1 - Publisher Copyright:
© 2023 American Institute of Physics Inc.. All rights reserved.
PY - 2023/1/24
Y1 - 2023/1/24
N2 - Microbial infections cause many diseases. Synthetic antibiotics can treat infection, but their use in the long term causes microbial resistance. The nanoparticle preparation is well known to increase the effectiveness of a natural material as an antimicrobial. This research aims to determine the antimicrobial activity of C. mangga nanoparticles in vitro. Manufacture of nanoparticles using the ionic gelation method. Inhibition zone test for C. mangga nanoparticles with a concentration of 2.5% using the Kirby-Bauer method. Tests for Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using the microdilution method with variations in concentrations of 2.5%, 1.25%, 0.625%, 0.313%, 0.156% and 0.078%. The zone of inhibition of C. mangga nanoparticles against E. coli was 11.46 ± 1.07 mm (strong), against C. albicans 11.04 ± 1.26 mm (strong), and S. aureus 6.40 ± 1.77 mm (moderate). The MIC and MBC test values of E. coli were 1.25% and 2.5%, while S. aureus was 0.625% and 1.25%, and C. albicans was 0.313% and 0.625%. C. mangga nanoparticles have good potential as natural antimicrobial agents against bacteria and fungi.
AB - Microbial infections cause many diseases. Synthetic antibiotics can treat infection, but their use in the long term causes microbial resistance. The nanoparticle preparation is well known to increase the effectiveness of a natural material as an antimicrobial. This research aims to determine the antimicrobial activity of C. mangga nanoparticles in vitro. Manufacture of nanoparticles using the ionic gelation method. Inhibition zone test for C. mangga nanoparticles with a concentration of 2.5% using the Kirby-Bauer method. Tests for Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using the microdilution method with variations in concentrations of 2.5%, 1.25%, 0.625%, 0.313%, 0.156% and 0.078%. The zone of inhibition of C. mangga nanoparticles against E. coli was 11.46 ± 1.07 mm (strong), against C. albicans 11.04 ± 1.26 mm (strong), and S. aureus 6.40 ± 1.77 mm (moderate). The MIC and MBC test values of E. coli were 1.25% and 2.5%, while S. aureus was 0.625% and 1.25%, and C. albicans was 0.313% and 0.625%. C. mangga nanoparticles have good potential as natural antimicrobial agents against bacteria and fungi.
UR - http://www.scopus.com/inward/record.url?scp=85147289885&partnerID=8YFLogxK
U2 - 10.1063/5.0115289
DO - 10.1063/5.0115289
M3 - Conference contribution
AN - SCOPUS:85147289885
T3 - AIP Conference Proceedings
BT - 4th International Conference on Life Science and Technology, ICoLiST 2023
A2 - Taufiq, Ahmad
A2 - Susanto, Hendra
A2 - Wang, I. Ching
A2 - Nur, Hadi
A2 - Aziz, Muhammad
A2 - Chang, Chuang-Rung
A2 - Elbers, Gereon
A2 - Lestari, Sri Rahayu
A2 - Diantoro, Markus
A2 - Mufti, Nandang
A2 - Ng, Chen Siang
A2 - Malek, Nik Ahmad Nizam Nik
A2 - Sunaryono, null
A2 - Chiu, Yu-Hsin
A2 - Zubaidah, Siti
A2 - Aulanni'am, null
A2 - Wibowo, Indra
A2 - Handaya, Adeodatus Yuda
PB - American Institute of Physics Inc.
T2 - 4th International Conference on Life Science and Technology, ICoLiST 2023
Y2 - 31 August 2021
ER -