Evaluation of storage length to blood component platelet concentrate quality in the blood bank, Dr. Soetomo General Hospital, Surabaya, Indonesia

Dhinasty Armenia, Betty Agustina Tambunan

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Storage of Platelet Concentrate (PC) can cause changes in thrombocyte quality that affect thrombocyte viability and decrease hemostatic function. All biochemical, structural and functional changes to platelets during storage in the Blood Bank are known as platelet storage lesions. To analyze the effect of storage length on changes in thrombocyte morphology and function as well as the metabolic parameters of platelet concentrate bag components. This was an analytical study with time series design. Sampling was done consecutively. Samples were new PC bags which were processed and stored at room temperature with agitation during June-July 2019 in the Blood Bank of the Dr. Soetomo General Hospital, Surabaya. Examination of platelet count and MPV were performed to determine morphological changes and metabolic parameters like pH, pCO2, and pO2 on day 1, day 3, and day 5th. Data were analyzed by using Shapiro-Wilk test, Paired t test and Wilcoxon Signed Rank Test. There were significant changes in MPV, pH, and pCO2 values during storage (p <0.05). However, there were no significant changes in platelet count and pO2 value. Metabolic changes in PC bag were obtained but there was no decrease in platelet count so that the PC component was still feasible to be given to the patient. Further research is needed for other parameters that can be affected by the storage process.

Original languageEnglish
Pages (from-to)908-913
Number of pages6
JournalIndian Journal of Forensic Medicine and Toxicology
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • Platelet concentrate
  • Platelet storage lesion
  • Quality

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