Evaluation of Physical Quality and Antioxidant Activity of Ethanol Extract of Moringa Leaves (Moringa oleifera LAM) Formulated in Emulgel Preparation

Benni Iskandar, Gressy Novita, Fiona Fitri Annisa, Leny, Ihsanul Hafiz, Meircurius D.C. Surboyo, Ching Kuo Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Moringa leaves contains flavonoids which has the activity of free radical scavenging or as an antioxidant. The purpose of this study was to formulate the water insoluble extract of Moringa leaves into emulgel dosage forms in various concentrations to produce a stable preparation during storage and have antioxidant activity. The formulation of the emulgel preparation was made by varying the concentration of the ethanol extract of Moringa leaves at 0%(F0), 0.5%(FI), 1%(FII), and 2%(FIII). The study examined the emulgel preparation including organoleptic test, irritation test, pH test, homogeneity test, emulsion type test, spreadability test, freeze and thaw stability and antioxidant properties by using DPPH method. The results showed that all emulgel preparations were stable during storage, did not irritate, pH value between 5.50-6.04, homogeneous preparation, emulsion type was oil on water phase (o/w), spreadability between 3.2-3.9cm, IC50 from ethanol extract of Moringa leaves was 135.539ppm. For emulgel preparation, FIII formulation showed best activity compared to another formula in its capacity which was 192.48 ppm for 1st week storage and 292.94ppm for the 8th week storage. The conclusion of this study shows that emulgel containing Moringa leaf extract has antioxidant activity and stable in physical properties during storage.

Original languageEnglish
Pages (from-to)2703-2708
Number of pages6
JournalResearch Journal of Pharmacy and Technology
Volume15
Issue number6
DOIs
Publication statusPublished - Jun 2022

Keywords

  • Antioxidant
  • Moringa oleifera
  • emulgel
  • extract

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