TY - JOUR
T1 - Evaluation of osteogenic properties after application of hydroxyapatite-based shells of Portunus pelagicus
AU - Kamadjaja, Michael Josef Kridanto
AU - Gatia, Alya Nisrina Sajidah
AU - Novitananda, Agtadilla
AU - Maudina, Lintang
AU - Laksono, Harry
AU - Dahlan, Agus
AU - Tumali, Bambang Agustono Satmoko
AU - Ari, Muhammad Dimas Aditya
N1 - Publisher Copyright:
© Dental Journal 2021.
PY - 2021/9
Y1 - 2021/9
N2 - Background: After tooth extraction, the socket leaves a defect on the alveolar bone. The administration of shell crab-derived hydroxyapatite maintains bone dimensions that are important for achieving successful prosthodontic treatment. Purpose: The aim of the study was to determine the osteogenic properties, such as the number of osteoclasts, osteoblasts and osteocytes, after the application of hydroxyapatite-based shell crab in the post-extraction sockets of Wistar rats. Methods: There were two groups: the control group (K) and the treatment group (T). Wistar rats were randomly divided into control and treatment groups. After tooth extraction, hydroxyapatite gel derived from Portunus pelagicus shells was applied to the tooth sockets of Wistar rats. Observations and calculations of osteoclasts, osteoblasts and osteocytes were carried out on the 14th and 28th days under a light microscope with 400 times magnification. Statistical analysis was performed using one-way ANOVA. Results: There was a significant difference (p<0.05) between the K14 and P14 groups, K28 and P28 groups, K14 and K28 groups, and P14 and P28 groups. The results indicated that there were significant differences between groups of variables. Conclusion: The application of shell crab-derived hydroxyapatite (Portunus pelagicus) was able to decrease the number of osteoclasts and increase the number of osteoblasts and osteocytes.
AB - Background: After tooth extraction, the socket leaves a defect on the alveolar bone. The administration of shell crab-derived hydroxyapatite maintains bone dimensions that are important for achieving successful prosthodontic treatment. Purpose: The aim of the study was to determine the osteogenic properties, such as the number of osteoclasts, osteoblasts and osteocytes, after the application of hydroxyapatite-based shell crab in the post-extraction sockets of Wistar rats. Methods: There were two groups: the control group (K) and the treatment group (T). Wistar rats were randomly divided into control and treatment groups. After tooth extraction, hydroxyapatite gel derived from Portunus pelagicus shells was applied to the tooth sockets of Wistar rats. Observations and calculations of osteoclasts, osteoblasts and osteocytes were carried out on the 14th and 28th days under a light microscope with 400 times magnification. Statistical analysis was performed using one-way ANOVA. Results: There was a significant difference (p<0.05) between the K14 and P14 groups, K28 and P28 groups, K14 and K28 groups, and P14 and P28 groups. The results indicated that there were significant differences between groups of variables. Conclusion: The application of shell crab-derived hydroxyapatite (Portunus pelagicus) was able to decrease the number of osteoclasts and increase the number of osteoblasts and osteocytes.
KW - Portunus pelagicus
KW - hydroxyapatite
KW - osteoblasts
KW - osteoclasts
KW - osteocytes
UR - http://www.scopus.com/inward/record.url?scp=85147469628&partnerID=8YFLogxK
U2 - 10.20473/J.DJMKG.V54.I3.P119-123
DO - 10.20473/J.DJMKG.V54.I3.P119-123
M3 - Article
AN - SCOPUS:85147469628
SN - 1978-3728
VL - 54
SP - 119
EP - 123
JO - Dental Journal
JF - Dental Journal
IS - 3
ER -