Evaluation of Eerum Biochemical, Plasma Catecholamine and Serum Cortisol in Delman Horses with Mild Colic after Various NSAIDs Drug Administration: A Comparative Study

This study aimed to compare the administration of various NSAIDs drug on serum biochemistry, plasma catecholamines and serum cortisol in Delman horses associated with mild colic. A total of 32 horses were evaluated due to mild colic. Flunixin, ketoprofen, and phenylbutazone were administered intravenously at the recommended dose rates of 1.0; 2.2 and 4.4 mg/kg, respectively. Administration of the NSAIDs commenced on Day 1 and continued every 12 h for 12 days. Blood samples collected between days 2, 5, 9 and 13 to evaluate AST, ALP, GGT, creatinine, urea, epinephrine, norepinephrine, and cortisol level. The data analysis was performed using Multivariate analysis of variance (Manova) followed by Duncan multiple range test. The results showed a significant alleviation in all observed variables on Day 13, although the use of various NSAIDs showed no significant difference.