Evaluation of BSP and DMP1 in hydroxyapatite crab shells used for dental socket preservation

Michael Josef Kridanto Kamadjaja, Sherman Salim, Wiwik Herawati Waluyo, Tengku Natasha Eleena binti Tengku Ahmad Noor

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Bone resorption due to tooth extraction leads to unpredictable bone volume for future prosthetics. Crab shells were promoted as a solution to prevent bone resorption, along with an effort to reduce biological waste. Purpose: This study aimed to analyze the expression of bone sialoprotein (BSP) and dentine matrix protein-1 (DMP1) in the wound healing process in tooth-extraction sockets after applying a crab shell-derived hydroxyapatite scaffold. Methods: The subjects (28 Cavia cobaya) were divided into control and treatment groups. The control group was left untreated, while the treatment group received a hydroxyapatite scaffold of Portunus pelagicus shell in the tooth socket. The expression of BSP and DMP1 was determined by immunohistochemical staining on days 7 and 14. One-way analysis of variance and Tukey’s honest significance difference test were used to find the groups with the most significant difference. Results: The highest mean expression of BSP and DMP1 was in the day 14 treatment group, while the lowest was in the day 7 control group. Conclusion: Administering hydroxyapatite scaffold derived from the Portunus pelagicus shell to the post-extraction sockets increased the expression of both BSP and DMP1.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalDental Journal
Issue number2
Publication statusPublished - 2023


  • BSP
  • DMP1
  • crab shell
  • hydroxyapatite
  • medicine


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