Estragole: A review of its pharmacology, effect on animal health and performance, toxicology, and market regulatory issues

Estragole is a volatile terpenoid molecule found in various plants or components, frequently in very high concentrations. It has been demonstrated to increase animal health and output performance effectively. Estragole has been shown to possess antioxidant properties both in vitro and in vivo. These properties include the ability to raise GSH and GPx levels, as well as the ability to suppress toxic materials and maintain cellular redox status, MDA activity, and MPO activity. In addition, it produces anti-inflammatory and immunomodulatory effects via the production/release of cytokines, substance P, bradykinin, histamine, serotonin, cytokines, and nitric oxide (NO), and it induces a substantial leukocyte migration. Further, Estragole gives protection against bacteria and viruses. The objective of this review was to briefly discuss the natural sources of Estragole, its chemistry, its extraction, its bioavailability, absorption, distribution, toxicity, and carcinogenicity, and its biomedical effects in vivo or in vitro are discussed in this review. The market for Estragole, as well as its regulatory framework also explained in this study.