Epigenetics Approaches toward Precision Medicine for Idiopathic Pulmonary Fibrosis: Focus on DNA Methylation

Wiwin Is Effendi, Tatsuya Nagano

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Genetic information is not transmitted solely by DNA but by the epigenetics process. Epigenetics describes molecular missing link pathways that could bridge the gap between the genetic background and environmental risk factors that contribute to the pathogenesis of pulmonary fibrosis. Specific epigenetic patterns, especially DNA methylation, histone modifications, long non-coding, and microRNA (miRNAs), affect the endophenotypes underlying the development of idiopathic pulmonary fibrosis (IPF). Among all the epigenetic marks, DNA methylation modifications have been the most widely studied in IPF. This review summarizes the current knowledge concerning DNA methylation changes in pulmonary fibrosis and demonstrates a promising novel epigenetics-based precision medicine.

Original languageEnglish
Article number1047
JournalBiomedicines
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2023

Keywords

  • DNA methylation
  • chronic pulmonary diseases
  • epigenetics
  • epigenomics
  • histone modification
  • idiopathic pulmonary fibrosis
  • long noncoding
  • microRNA

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