TY - JOUR
T1 - Epigallocathecingallate (EGCG) antifungal properties for candida isolates from HIV/AIDS patients with oral candidiasis in compare with fluconazole
AU - Murtiastutik, Dwi
AU - Prakoswa, Cita Rosita Sigit
AU - Tantular, Indah Setyawati
AU - Wibisono, Yusuf
AU - Hidayati, Afif Nurul
AU - Sawitri,
AU - Listiawan, Muhammad Yulianto
N1 - Publisher Copyright:
© 2021, Institute of Medico-Legal Publications. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients. Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been many studies focusing on natural substances and its antifungal properties. In this study, a form of green tea extract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective: To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates taken from HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patients with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results: The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC of fluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MIC values for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value of fluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidal effect is better than fluconazole.
AB - Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients. Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been many studies focusing on natural substances and its antifungal properties. In this study, a form of green tea extract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective: To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates taken from HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patients with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results: The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC of fluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MIC values for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value of fluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidal effect is better than fluconazole.
KW - Antifungal activity
KW - Candida albicans
KW - Candida non-albicans
KW - EGCG
KW - Fluconazole
KW - HIV/AIDS
KW - Oral candidiasis
UR - http://www.scopus.com/inward/record.url?scp=85099938558&partnerID=8YFLogxK
U2 - 10.37506/ijfmt.v15i1.13551
DO - 10.37506/ijfmt.v15i1.13551
M3 - Article
AN - SCOPUS:85099938558
SN - 0973-9122
VL - 15
SP - 1027
EP - 1029
JO - Indian Journal of Forensic Medicine and Toxicology
JF - Indian Journal of Forensic Medicine and Toxicology
IS - 1
ER -