Enhancement of solubility and dissolution rate of quercetin with solid dispersion system formation using hydroxypropyl methyl cellulose matrix

Dwi Setyawan, A. Ahmad Fadhil, Dayanara Juwita, Helmy Yusuf, Retno Sari

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Objective: The aim of the present study was to obtain raw quercetin materials using solid dispersion (SD) system with higher solubility and dissolution rate than pure quercetin. Materials and Methods: The SD of quercetin-hydroxypropyl methyl cellulose (HPMC) was prepared by solvent method. Subsequently, the SD was tested for its solubility and in vitro dissolution. The physicochemical properties were characterized by powder X-ray diffractometer, differential thermal analyzer, FT-infrared spectrophotometer, and scanning electron microscope. Results: Solubility test, dissolution test, and physicochemical property characterization on the SD of Quercetin-HPMC were then compared to pure quercetin and the physical mixture. Based on the results of one-way analysis of variance test, α = 0.05 indicated a significant difference in the solubility and dissolution rate. Conclusions: Quercetin-HPMC SD was in substance which resulted in the increase of solubility and dissolution rate. These findings may enhance bioavailability to increase drug efficacy.

Original languageEnglish
JournalThai Journal of Pharmaceutical Sciences
Volume41
Issue number3
Publication statusPublished - 2017

Keywords

  • Dissolution test
  • Hydroxypropyl methyl cellulose
  • Quercetin
  • Solid dispersion
  • Solubility

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