TY - JOUR
T1 - Elderly immunity improvement after getting sinbiotic and zinc combinations
AU - Hartono, Rudy
AU - Ipa, Agustian
AU - Wirjatmadi, Bambang
AU - Amir, Aswita
AU - Kapoor, Gaurav
AU - Nugroho, Heru Santoso Wahito
N1 - Publisher Copyright:
© 2018, Indian Journal of Public Health Research and Development. All rights reserved.
PY - 2018/11
Y1 - 2018/11
N2 - Elderly is one group of people who have a risk of changing immune function. Changes in immune function in the elderly, especially in the immune system mediated by cells. In accordance with the increase in age, coronary heart disease, cancer, autoimmune diseases, and other chronic diseases. The increasing number of elderly people is one indicator of the success of development as well as a challenge in development. The purpose of this study was to analyze the improvement of elderly immunity after getting synbiotics and zinc. The type of this research was an experimental study in which volunteers were given zinc + synbiotic combination supplements. Further measurements of IL-2, IFN-γ and IL-10 were carried out. Furthermore, the measurement results were compared to find out the differences in elderly immune expression. Analysis of normality and homogeneity to determine parametric or non-parametric statistical tests with the Shapiro-Wilk test if it meets parametric requirements then the analysis used in this study was t-test to evaluate the effect of supplementation (pre-post test). The results showed that synbiotic + zinc combination supplementation could potentially increase IL-2 profile (p = 0.000), IFN-γ (p = 0.019), and IL-10 (p = 0.010) significantly in the elderly. Based on the results, it could be concluded that synbiotic + zinc combination supplementation has the potential to increase IL-2, IFN-γ, and IL-10 profiles in the elderly.
AB - Elderly is one group of people who have a risk of changing immune function. Changes in immune function in the elderly, especially in the immune system mediated by cells. In accordance with the increase in age, coronary heart disease, cancer, autoimmune diseases, and other chronic diseases. The increasing number of elderly people is one indicator of the success of development as well as a challenge in development. The purpose of this study was to analyze the improvement of elderly immunity after getting synbiotics and zinc. The type of this research was an experimental study in which volunteers were given zinc + synbiotic combination supplements. Further measurements of IL-2, IFN-γ and IL-10 were carried out. Furthermore, the measurement results were compared to find out the differences in elderly immune expression. Analysis of normality and homogeneity to determine parametric or non-parametric statistical tests with the Shapiro-Wilk test if it meets parametric requirements then the analysis used in this study was t-test to evaluate the effect of supplementation (pre-post test). The results showed that synbiotic + zinc combination supplementation could potentially increase IL-2 profile (p = 0.000), IFN-γ (p = 0.019), and IL-10 (p = 0.010) significantly in the elderly. Based on the results, it could be concluded that synbiotic + zinc combination supplementation has the potential to increase IL-2, IFN-γ, and IL-10 profiles in the elderly.
KW - IFN-γ
KW - IL-10
KW - IL-2
KW - Immune
KW - Zinc and synbiotic combination
UR - http://www.scopus.com/inward/record.url?scp=85058144546&partnerID=8YFLogxK
U2 - 10.5958/0976-5506.2018.01484.5
DO - 10.5958/0976-5506.2018.01484.5
M3 - Article
AN - SCOPUS:85058144546
SN - 0976-0245
VL - 9
SP - 380
EP - 383
JO - Indian Journal of Public Health Research and Development
JF - Indian Journal of Public Health Research and Development
IS - 11
ER -
