Ekstrak Etanol Kayu Secang (Caesalpinia sappan L.) Secara Topikal Efektif pada Kepadatan Kolagen Masa Penyembuhan Luka Insisi Tikus Putih

This study aimed to determine the effectiveness of Secang wood (Caesalpinia sappan L.) extract topically can increase the density of collagen on incision wound healing in albino rats (Rattus norvegicus). A total of 20 male rats were randomly devided into five groups, i.e., negative control (K-) treated with ointment base, positive control (K+) treated with povidone iodine 10% ointment, treated groups (P1; P2; P3) treated with Secang wood extract ointment 6.5%; 15%; 30%. Treatment had been given directly on the subcutan incision area topically once a day for fourteen days. The result data of histopatological appereance were analyzed with Kruskal-Wallis and Mann-Whitney. The collagen density of incision wound on group P1 significantly different with group P2, P3, K-, and K+, and there were no more significantly different groups. It can be concluded that increasing mean of collagen density on Secang wood extract ointment group P1 which indicates that is the optimum dose.