Nowadays, dengue disease is still a major health problem in Indonesia. However, Surabaya, the second-largest city in the country is endemic for dengue. Dengue virus (DENV) is the causative agent of dengue fever and dengue shock syndrome or dengue haemorrhagic fever. At present, no antiviral drugs are available for treatment DENV infections. Therefore, we aimed to investigate the antiviral activity of Allium cepa extract (ACE) against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia in 2013. Interestingly, we revealed that ACE inhibited DENV-2 in Vero cells with IC50: 1,932.36 ìg/mL, CC50: 121.17 ìg/mL and SI: 0.06. Notably, findings presented here suggest that ACE considered as low concerning antiviral activityagainst DENV-2. In sum, ACE should be considered for re-evaluation in the development of an effective antiviral compound against DENV-2.
|Number of pages||4|
|Journal||Biochemical and Cellular Archives|
|Publication status||Published - Oct 2020|
- Allium cepa
- Vero cell