EFFICACY OF ALLIUM CEPA (AMARYLLIDACEAE) EXTRACT AGAINST DENGUE VIRUS TYPE-2 (FLAVIVIRIDAE : FLAVIVIRUS) ISOLATED FROM SURABAYA, INDONESIA

Arif Nur Muhammad Ansori, Amaq Fadholly, Annise Proboningrat, Shara Jayanti, Suhailah Hayaza, Raden Joko Kuncoroningrat Susilo, Teguh Hari Sucipto, Soegeng Soegijanto

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6 Citations (Scopus)

Abstract

Nowadays, dengue disease is still a major health problem in Indonesia. However, Surabaya, the second-largest city in the country is endemic for dengue. Dengue virus (DENV) is the causative agent of dengue fever and dengue shock syndrome or dengue haemorrhagic fever. At present, no antiviral drugs are available for treatment DENV infections. Therefore, we aimed to investigate the antiviral activity of Allium cepa extract (ACE) against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia in 2013. Interestingly, we revealed that ACE inhibited DENV-2 in Vero cells with IC50: 1,932.36 ìg/mL, CC50: 121.17 ìg/mL and SI: 0.06. Notably, findings presented here suggest that ACE considered as low concerning antiviral activityagainst DENV-2. In sum, ACE should be considered for re-evaluation in the development of an effective antiviral compound against DENV-2.

Original languageEnglish
Pages (from-to)4783-4786
Number of pages4
JournalBiochemical and Cellular Archives
Volume20
Issue number2
Publication statusPublished - Oct 2020

Keywords

  • Allium cepa
  • DENV-2
  • Vero cell
  • antiviral

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