TY - JOUR
T1 - EFFICACY OF ALLIUM CEPA (AMARYLLIDACEAE) EXTRACT AGAINST DENGUE VIRUS TYPE-2 (FLAVIVIRIDAE : FLAVIVIRUS) ISOLATED FROM SURABAYA, INDONESIA
AU - Ansori, Arif Nur Muhammad
AU - Fadholly, Amaq
AU - Proboningrat, Annise
AU - Jayanti, Shara
AU - Hayaza, Suhailah
AU - Kuncoroningrat Susilo, Raden Joko
AU - Sucipto, Teguh Hari
AU - Soegijanto, Soegeng
N1 - Funding Information:
This study was approved by the Universitas Airlangga (24-934/UN3.14/PPd/2013), Surabaya, Indonesia. We thank EJA – Professional Translation Services for editing the manuscript. Institute of Tropical Disease (ITD) the Center of Excellence (COE) program by the Ministry of Research and Technology (KEMENRISTEK) of the Republic of Indonesia. PMDSU Scholarship - Batch III, which was awarded to Arif Nur Muhammad Ansori, Amaq Fadholly, Annise Proboningrat and Suhailah Hayaza.
Funding Information:
Zandi et al (2012) stated that the ideal drug would be cytotoxic only at very high concentrations and have antiviral activity at very low concentrations, thus yielding a high SI value and thereby able to eliminate the target virus at concentrations well below its cytotoxic concentration. In addition, the selectivity index of a compound is a widely accepted parameter used to express a compound’s in vitro efficacy in the inhibition of virus replication. Moreover, the establishment of new anti-DENV products from bioactive compounds is needful in order to find more effective and less toxic anti-DENV drugs (Sucipto et al, 2018). CONCLUSION Notably, findings presented here suggest that ACE considered as low concerning antiviral activity against DENV-2. In sum, ACE should be considered for reevaluation in the development of an effective antiviral compound against DENV-2. ACKNOWLEDGEMENT This study was approved by the Universitas Airlangga (24-934/UN3.14/PPd/2013), Surabaya, Indonesia. We thank EJA – Professional Translation Services for editing the manuscript. Institute of Tropical Disease (ITD) the Center of Excellence (COE) program by the Ministry of Research and Technology (KEMENRISTEK) of the Republic of Indonesia. PMDSU Scholarship - Batch III, which was awarded to Arif Nur Muhammad Ansori, Amaq Fadholly, Annise Proboningrat and Suhailah Hayaza.
Publisher Copyright:
© 2020 2020
PY - 2020/10
Y1 - 2020/10
N2 - Nowadays, dengue disease is still a major health problem in Indonesia. However, Surabaya, the second-largest city in the country is endemic for dengue. Dengue virus (DENV) is the causative agent of dengue fever and dengue shock syndrome or dengue haemorrhagic fever. At present, no antiviral drugs are available for treatment DENV infections. Therefore, we aimed to investigate the antiviral activity of Allium cepa extract (ACE) against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia in 2013. Interestingly, we revealed that ACE inhibited DENV-2 in Vero cells with IC50: 1,932.36 ìg/mL, CC50: 121.17 ìg/mL and SI: 0.06. Notably, findings presented here suggest that ACE considered as low concerning antiviral activityagainst DENV-2. In sum, ACE should be considered for re-evaluation in the development of an effective antiviral compound against DENV-2.
AB - Nowadays, dengue disease is still a major health problem in Indonesia. However, Surabaya, the second-largest city in the country is endemic for dengue. Dengue virus (DENV) is the causative agent of dengue fever and dengue shock syndrome or dengue haemorrhagic fever. At present, no antiviral drugs are available for treatment DENV infections. Therefore, we aimed to investigate the antiviral activity of Allium cepa extract (ACE) against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia in 2013. Interestingly, we revealed that ACE inhibited DENV-2 in Vero cells with IC50: 1,932.36 ìg/mL, CC50: 121.17 ìg/mL and SI: 0.06. Notably, findings presented here suggest that ACE considered as low concerning antiviral activityagainst DENV-2. In sum, ACE should be considered for re-evaluation in the development of an effective antiviral compound against DENV-2.
KW - Allium cepa
KW - DENV-2
KW - Vero cell
KW - antiviral
UR - http://www.scopus.com/inward/record.url?scp=85096471933&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85096471933
SN - 0972-5075
VL - 20
SP - 4783
EP - 4786
JO - Biochemical and Cellular Archives
JF - Biochemical and Cellular Archives
IS - 2
ER -
