Wrinkle is depressions of the skin that appears as a line on the skin, a major sign of skin aging. Laser is widely used for rejuvenation, but few reports that obtained in Indonesian skin. The increased melanin content in Indonesian skin can decrease therapeutic efficacy and promote adverse sequela. The Food and Drug Administration in 2014 gave clearance for picosecond 755 nm laser with diffractive lens array (DLA) in the treatment of wrinkles in skin types I–IV, the safety extends to patients of skin types IV–VI. This study investigated the efficacy and safety of picosecond 755 nm laser with DLA for wrinkle in forearm of the Indonesian patients. Twenty patients with Fitzpatrick skin type III–V were enrolled in this study. Clinical assessment of wrinkles was assessed with a dermatologic assessment form forearm photographic assessment scaled, and patients also rated their overall satisfaction. Evaluation was obtained at baseline and 1 month after treatment. Significant improvement in wrinkle at 1 month was noted (p < .05). Subject satisfaction indicated that 75% and 5% of patients were extremely satisfied and satisfied. No serious adverse events were reported. Picosecond 755 nm laser with DLA is an effective option for wrinkle in Indonesian skin without any adverse event.