Objective. Nigella sativa is a plant that contains a lot of antioxidants. Nigella sativa is an important medicinal herb that has been utilized for centuries. Given Nigella sativa efficacy in treating a variety of disorders, this systematic study attempts to assess Nigella sativa effect on the female reproductive system. Materials and methods. This systematic review was conducted on the Randomize Control Trial (RCT) through electronic databases such as Google Scholar, Science Direct, Pubmed, Scopus and Proquest from January 2012 to January 2022. The keywords or phrases used were Nigella sativa, Black Seeds, Black Cumin, Thymoquinonee, Infertility, Women dan Female. Results. 14 articles were selected for analysis. The results showed that Nigella sativa and its constituent, Thymoquinone can reduce MDA levels, increase SOD, increase TAS, increase the number of ovarian follicles, and increase body weight. Conclusion. Nigella sativa can improve reproductive parameters in women.