Microplastic (MP) and nanoplastic (NP) pollution in both sea and river reduces the function of aquatic biota habitats, including habitats of fish. The usage of rivers polluted by MP as a source of water in ponds or reservoirs for growth, development, and fish cultivation can reduce crop yields will disrupt the growth and development of fish thereby reducing its production. Supplementary from the Zingiberaceae is an alternative option to reduce the impact of MP pollution in fish body. This study aims to analyze the potential of several plants in Zingiberaceae group as a source of antioxidants for fish supplement to reduce the effects of oxidants caused by MP. Thirty-six tilapia fish were divided into two groups, control and treatment group with variations in MP concentrations (0, 1, and 10 mg.kg-1) and variations of supplementary source (Curcuma longa, Curcuma xanthorrhiza, and Alpinia galanga rhizomes). The results showed that medicinal plants of Zingiberaceae group were able to increase the growth of tilapia exposed to MP. Rhizoma oí Alpinia galanga gave the best effect followed by Curcuma longa and Curcuma xanthorrhiza.