Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial

Pouya Rostamizadeh, Seyed Mohammad Kazem Hosseini Asl, Zohreh Ghaem Far, Pegah Ahmadijoo, Trias Mahmudiono, Dmitry Olegovich Bokov, Fahad Alsaikhan, Behrooz Jannat, Zohreh Mazloom

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This study aimed to evaluate the effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease (NAFLD). In this randomized double-blind, placebo-controlled trial, 60 women with NAFLD were selected and randomly assigned into 2 groups to take 1,000 mg/day powder of licorice root extract or placebo for 12 weeks. In addition, all the patients were advised to follow a weight loss diet and healthy lifestyle. The plasma levels of liver enzymes, glycemic indices, lipid profile, oxidative stress parameters, as well as hepatic steatosis were measured at the beginning and end of the study. Through the 12-weeks period of supplementation, women who received powder of licorice root experienced a statistically significant improvement in alanine aminotransferase (p <.001), insulin (p =.002), insulin resistance (p =.003), malondialdehyde (p <.001) serum levels, and ultrasonographic findings of liver steatosis (p <.001), compared to the placebo group. In conclusion, licorice root supplementation in addition to gradual weight loss and lifestyle modification is superior to lifestyle modification alone for the treatment of NAFLD.

Original languageEnglish
Pages (from-to)3949-3956
Number of pages8
JournalPhytotherapy Research
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 2022

Keywords

  • herbal medicine
  • licorice
  • liver enzymes
  • nonalcoholic fatty liver disease

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