TY - JOUR
T1 - Effects of Labisia pumila on oxidative stress in rat model of post-menopausal osteoporosis
AU - Nurdiana, Nurdiana
AU - Mariati, Nelly
AU - Noorhamdani, Noorhamdani
AU - Setiawan, Bambang
AU - Budhiparama, Nicolaas
AU - Noor, Zairin
N1 - Publisher Copyright:
© 2016 Hainan Medical College
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objective To analyze the effects of Labisia pumila (L. pumila) extract on the markers of oxidative stress in ovariectomized rats. Methods Twenty-five female Wistar rats were divided into five treatment groups (n = 5): the control group, the ovariectomized group, the ovariectomized group treated with L. pumila extract of various doses (10 mg/kg, 20 mg/kg, and 40 mg/kg). L. pumila extract was administered daily for 8 weeks. Results The levels of malondialdehyde and superoxide dismutase (SOD) were subjected to spectrophotometric analysis. Serum levels of malondialdehyde and SOD were significantly higher in the group of rat model of post-menopausal osteoporosis than that of the control group (P < 0.05). All doses of L. pumila administered significantly decreased the serum levels of malondialdehyde relative to the group of rat model of post-menopausal osteoporosis, reaching the levels comparable to those of the control group (P < 0.05). The second dose of L. pumila significantly decreased the levels of SOD relative to those of the group of rat model of post-menopausal osteoporosis, although it did not reach the levels of SOD of the control group (P < 0.05). Conclusion The ethanol extract of L. pumila normalizes lipid peroxidation in the rat model of post-menopausal osteoporosis via the mechanism of endogenous antioxidant replacement.
AB - Objective To analyze the effects of Labisia pumila (L. pumila) extract on the markers of oxidative stress in ovariectomized rats. Methods Twenty-five female Wistar rats were divided into five treatment groups (n = 5): the control group, the ovariectomized group, the ovariectomized group treated with L. pumila extract of various doses (10 mg/kg, 20 mg/kg, and 40 mg/kg). L. pumila extract was administered daily for 8 weeks. Results The levels of malondialdehyde and superoxide dismutase (SOD) were subjected to spectrophotometric analysis. Serum levels of malondialdehyde and SOD were significantly higher in the group of rat model of post-menopausal osteoporosis than that of the control group (P < 0.05). All doses of L. pumila administered significantly decreased the serum levels of malondialdehyde relative to the group of rat model of post-menopausal osteoporosis, reaching the levels comparable to those of the control group (P < 0.05). The second dose of L. pumila significantly decreased the levels of SOD relative to those of the group of rat model of post-menopausal osteoporosis, although it did not reach the levels of SOD of the control group (P < 0.05). Conclusion The ethanol extract of L. pumila normalizes lipid peroxidation in the rat model of post-menopausal osteoporosis via the mechanism of endogenous antioxidant replacement.
KW - Antioxidants
KW - Lipid peroxidation
KW - Ovariectomy
KW - Oxidative damage
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84991644094&partnerID=8YFLogxK
U2 - 10.1016/j.apjr.2016.07.015
DO - 10.1016/j.apjr.2016.07.015
M3 - Article
AN - SCOPUS:84991644094
SN - 2305-0500
VL - 5
SP - 391
EP - 394
JO - Asian Pacific Journal of Reproduction
JF - Asian Pacific Journal of Reproduction
IS - 5
ER -